Bioactive Small Molecules
Medchemexpress LLC Gsk1324726a | 1300031-52-0 | 99.9% | 434.91 | 100 MG
GSK1324726A, also known as I-BET726, is a novel, potent, and selective inhibitor of BET proteins. It demonstrates high affinity for BRD2, BRD3, and BRD4, and has shown significant inhibition of neuroblastoma tumor growth both in vitro and in vivo.
- Potent and selective inhibitor of BET proteins
- High affinity for BRD2 (IC50=41 nM), BRD3 (IC50=31 nM), and BRD4 (IC50=22 nM)
- Causes potent growth inhibition and cytotoxicity in neuroblastoma cell lines
- Inhibits neuroblastoma tumor growth in models
AdipoGen DSP-2
Chemical. CAS 1609395-31-4. Formula C27H14FNO8. MW 499.4. Synthetic Control for H2S2 and hydrogen polysulfides probes.
Medchemexpress LLC B7-H2/ICOSLG Human 50ug | 50ug
B7-H2/ICOSLG Protein a ligand for T-cell receptor ICOS critically costimulates T-cell proliferation and cytokine secretion It induces B-cell proliferation and supports plasma cell differentiation playing a key role in local tissue responses to inflammation B7-H2/ICOSLG also modulates the secondary immune response by co-stimulating memory T-cell function In molecular interactions it has been observed to interact with CTLA4 in vitro B7-H2/ICOSLG Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived B7-H2/ICOSLG protein expressed by HEK293 with C-Avi C-His labeled tag
Cayman Chemical 3 4MethylendIoxyamethylpr 5mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
AdipoGen Simvastatin (10 mg)
Chemical. CAS: 79902-63-9. Formula: C25H38O5. MW: 418.6. Synthetic. Synthetic analog of Lovastatin (Prod. No. AG-CN2-0051 http://www.adipogen.com/ag-cn2-0051/lovastatin.html ). Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. Inhibits the isoprenylation of Ras and Rho family GTPases. Smooth muscle cell proliferation inhibitor. Anti-adhesive, immunomodulatory and anti-inflammatory compound. Proteasome modulator. Stimulates bone formation. Apoptosis inducer. Anticancer compound. Increases cellular resistance to anticancer agents such as doxorubicin and etoposides (Prod. No. AG-CR1-3572 http://www.adipogen.com/ag-cr1-3572/etoposide.html ). Suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection. Anti-hypertensive agent. Suppresses TNF-induced NF-kappaB activation.
Medchemexpress LLC H-Gly-Leu-Phe-OH | 103213-38-3 | 99.4% | 335.40 | 10 MG
H-Gly-Leu-Phe-OH (GLF) is an immunostimulatory tripeptide derived from α-lactalbumin. It has been shown to inhibit alopecia, epidermal thickening, and the thinning of the adipocyte layer induced by the anticancer agent Etoposide. This makes it a potential subject for research in various biological contexts, especially concerning its protective effects against drug-induced side effects.
- Immunostimulatory tripeptide.
- Derived from α-lactalbumin.
- Inhibits Etoposide-induced alopecia.
- Prevents epidermal thickening and adipocyte layer thinning.
- Suitable for research use.
Cayman Chemical Globosuxnthon A 5mg
A fungal metabolite; cytotoxic to various human solid tumor cell lines, including MCF-7, PC3, LNCap, and DU145 cells (IC50s = 1.3, 0.65, 1.5, and 1.2 µM, respectively); active against C. albicans
Selleck Chemical LLC 25-Hydroxy vitamin D2-d3 E8246-1MG
25-Hydroxy vitamin D2-d3 is the deuterated form of (22Z)-25-OH-D2 (22Z)-25-OH-D2 is a metabolic intermediate of vitamin D and is produced by hydroxylation in the liver
AdipoGen BTBCT
Chemical. CAS 525560-81-0. Formula C26H15ClF6O6S. MW 604.9. Synthetic. Suitable for the fluorometric detection of EU3.
AdipoGen S Ascochin
Chemical. CAS 935699-58-4. Formula C12H10O5. MW 234.2. Isolated from Ascochyta sp. Antibiotic. Antifungal and phytotoxic.
Cayman Chemical NBD-FTY720 phenoxy hydrochlo
A fluorescently-labeled analog of FTY720; methanol side chain of FTY720 that is targeted for phosphorylation by sphingosine kinases is retained, suggesting that it would likewise be phosphorylated in vivo
Apexbio Technology LLC HPOB 1429651-50-2 10mg
HPOB (CAS 1429651-50-2) is a selective inhibitor of histone deacetylase 6 (HDAC6) exhibiting an IC50 of 56 nM and over 30-fold reduced potency against other HDAC isoforms HDAC6 is a zinc-dependent deacetylase involved in the regulation of microtubule dynamics and protein quality control through its dual catalytic domains and a C-terminal ubiquitin-binding domain In cell-based assays HPOB induces -tubulin acetylation without affecting histone acetylation and inhibits the proliferation of normal HFS and modified LNCaP cells while preserving cell viability Additionally HPOB enhances the cytotoxic effects of etoposide doxorubicin and SAHA in transformed cells by promoting apoptosis and activating DNA damage response pathways In vivo HPOB is well tolerated in mice bearing human prostate cancer xenografts and augments the antitumor activity of SAHA
Selleck Chemical LLC Avatrombopag hydrochloride E4969-1G
Avatrombopag hydrochloride(AKR-501 hydrochloride YM477 hydrochloride) is an orally administered second generation agonist of Thrombopoietin receptor(TpoR) with an EC50 value of 3 3 nM It is used in the treatment of primary chronic immune thrombocytopenia (ITP)
